Selected Publications
Lodato lab members in bold
2022
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Ziegenfuss, J.S., Lodato, M.A. The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons. Frontiers in Aging, 12 Oct 2022. doi.org/10.3389/fragi.2022.991460. Link
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Choudhury, S., Huang, A.Y., Kim, J., Zhou, Z., Morillo, K., Maury, E.A., Tsai, J.W., Miller, M.B., Lodato, M.A., Araten, S., Hilal, N., Lee, E.A.#, Chen, M.H.#, Walsh, C.A#. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nature Aging. doi.org/10.1038/s43587-022-00261-5. Link
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Miller, M.B.*, Huang, A.Y.*, Kim, J., Zhou, Z., Kirkham, S.L., Maury, E.A., Ziegenfuss, J.S., Reed, H.C., Neil, J.E., Rento, L., Ryu, S.C., Ma, C.C., Luquette, L.J., Ames, H.M., Oakley, D.H., Frosch, M.P., Hyman, B.T., Lodato, M.A.#, Lee, E.A.#, and Walsh, C.A.# Somatic genomic changes in single Alzheimer's disease neurons. Nature.10.1038/s41586-022-04640-1.Link
Covered in The Boston Globe, AlzForum, U.S. News and World Report, and others.
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Bourseguin, J., Cheng, W., Talbot, E., Hardy, L., Lai, J., Jeffries, A.M., Lodato, M.A., Lee, E.A., Khoronenkova, S.V. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic Acids Research. https://doi.org/10.1093/nar/gkac104. Link
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2021
Lai, J., Kim, J., Jeffries, A.M., Tolles, A., Chittenden, T.W., Buckley, P.G., Yu, T.W., Lodato, M.A#., Lee, E.A.# Single-nucleus transcriptomic analyses reveal microglial activation underlying cerbellar degeneration in Ataxia Telangiectasia. bioRxiv, https://doi.org/10.1101/2021.09.09.459619 Link
Luquette, L.J., Miller, M.B., Zhou, Z., Bohrson, C.L., Galor, A., Lodato, M.A., Gawad, C., West, J., Walsh, C.A., Park,. P.J. Ultraspecific somatic SNV and indel detections in single neurons using primary template-directed amplification. bioRxiv. https://doi.org/10.1101/2021.04.30.442032. Link
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2020
Kim, J., Zhao, B., Huang, A.Y., Miller, M.B., Lodato, M.A., Walsh, C.A., and Lee, E.A. APP gene copy number changes reflect exogenous contamination. Nature 584, E20-E28. Link
2019
Lodato, M.A., and Walsh, C.A. Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet 28, R197-R206. Link
Bohrson, C.L., Barton, A.R., Lodato, M.A., Rodin, R.E., Luquette, L.J., Viswanadham, V.V., Gulhan, D.C., Cortes-Ciriano, I., Sherman, M.A., Kwon, M., et al. Linked-read analysis identifies mutations in single-cell DNA-sequencing data. Nat Genet 51, 749-754. Link
2018
Lodato, M.A*., Rodin, R.E*., Bohrson, C.L*., Coulter, M.E*., Barton, A.R*., Kwon, M*., Sherman, M.A., Vitzthum, C.M., Luquette, L.J., Yandava, C., et al. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science 359, 555-559. Link
Covered in Yahoo! News, GenomeWeb, and others.
2017
Sherman, M.A., Barton, A.R., Lodato, M.A., Vitzthum, C., Coulter, M.E., Walsh, C.A., and Park, P.J. PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic Acids Res. Link
McConnell, M.J., Moran, J.V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J.A., Fasching, L., Flasch, D.A., Freed, D., Ganz, J., Jaffe, A.E., Kwan, K.Y., Kwon, M., Lodato, M.A., Mills, R.E., Paquola, A.C.M., Rodin, R.E., Rosenbluh, C., Sestan, N., Sherman, M.A., Shin, J.H., Song, S., Straub, R.E., Thorpe, J., Weinberger, D.R., Urban, A.E., Zhou, B., Gage, F.H., Lehner, T., Senthil, G., Walsh, C.A., Chess, A., Courchesne, E., Gleeson, J.G., Kidd, J.M., Park, P.J., Pevsner, J., Vaccarino, F.M., and Brain Somatic Mosaicism, N. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science.10.1126/science.aal1641. Link
2015
Lodato, M.A*., Woodworth, M.B.*, Lee, S.*, Evrony, G.D., Mehta, B.K., Karger, A., Lee, S., Chittenden, T.W., D'Gama, A.M., Cai, X., et al. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science 350, 94-98. Link
Covered in the Wall Street Journal, The Atlantic, Science, Scientific American, and others.
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