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Selected Publications
Lodato lab members in red


ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

J. Lai, Demirbas, D., J. Kim, A. M. Jeffries, A. Tolles, Park, J., T. W. Chittenden, P. G. Buckley, T. W. Yu, M. A. Lodato# and E. A. Lee#

Cell Reports 43, 113622


Single-cell transcriptomic and genomic changes in the aging human brain

A. M. Jeffries*, T. Yu*, J. S. Ziegenfuss, A. Tolles, Y. Kim, Z. Weng#, and M. A. Lodato#

bioRxiv 2023.11.07.566050; doi:

Somatic mutations, genome mosaicism and aging

M. A. Lodato# and J. Vijg#

Frontiers in Aging 3, 1115408 10.3389/fragi.2022.1115408



Somatic genomic changes in single Alzheimer's disease neurons

M. B. Miller*, A. Y. Huang*, J. Kim, Z. Zhou, S. L. Kirkham, E. A. Maury, J. S. Ziegenfuss, H. C. Reed, J. E. Neil, L. Rento, S. C. Ryu, C. C. Ma, L. J. Luquette, H. M. Ames, D. H. Oakley, M. P. Frosch, B. T. Hyman, M. A. Lodato#, E. A. Lee#and C. A. Walsh#

Nature 604, 714-722 10.1038/s41586-022-04640-1. Covered in The Boston Globe, AlzForum, U.S. News and World Report, and others.

Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction

J. Bourseguin, W. Cheng, E. Talbot, L. Hardy, J. Lai, A. M. Jeffries, M. A. Lodato, E. A. Lee and S. V. Khoronenkova

Nucleic Acids Research 50, 2700-2718 10.1093/nar/gkac104


Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity

S. Choudhury, A. Y. Huang, J. Kim, Z. Zhou, K. Morillo, E. A. Maury, J. W. Tsai, M. B. Miller, M. A. Lodato, S. Araten, N. Hilal, E. A. Lee#, M. H. Chen# and C. A. Walsh#

Nature Aging 2, 714-725 10.1038/s43587-022-00261-5


Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders

J. Kim, A. Y. Huang, S. L. Johnson, J. Lai, L. Isacco, A. M. Jeffries, M. B. Miller, M. A. Lodato, C. A. Walsh# and E. A. Lee#

Nature Communications 13, 5918 10.1038/s41467-022-33642-w


The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons

J. S. Ziegenfuss and M. A. Lodato

Frontiers in Aging 3, 991460 10.3389/fragi.2022.991460


Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

L. J. Luquette*, M. B. Miller*, Z. Zhou, C. L. Bohrson, Y. Zhao, H. Jin, D. Gulhan, J. Ganz, S. Bizzotto, S. Kirkham, T. Hochepied, C. Libert, A. Galor, J. Kim, M. A. Lodato, J. I. Garaycoechea, C. Gawad, J. West, C. A. Walsh# and P. J. Park#

Nature Genetics 54, 1564-1571 10.1038/s41588-022-01180-2


APP gene copy number changes reflect exogenous contamination

J. Kim, B. Zhao, A. Y. Huang, M. B. Miller, M. A. Lodato, C. A. Walsh# and E. A. Lee#

Nature 584, E20-E28 10.1038/s41586-020-2522-3


Linked-read analysis identifies mutations in single-cell DNA-sequencing data

C. L. Bohrson, A. R. Barton, M. A. Lodato, R. E. Rodin, L. J. Luquette, V. V. Viswanadham, D. C. Gulhan, I. Cortes-Ciriano, M. A. Sherman, M. Kwon, M. E. Coulter, A. Galor, C. A. Walsh and P. J. Park

Nature Genetics 51, 749-754 10.1038/s41588-019-0366-2


Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

M. A. Lodato and C. A. Walsh

Human Molecular Genetics 28, R197-R206 10.1093/hmg/ddz191



Aging and neurodegeneration are associated with increased mutations in single human neurons

M. A. Lodato*, R. E. Rodin*, C. L. Bohrson*, M. E. Coulter*, A. R. Barton*, M. Kwon*, M. A. Sherman, C. M. Vitzthum, L. J. Luquette, C. Yandava, P. Yang, T. W. Chittenden, N. E. Hatem, S. C. Ryu, M. B. Woodworth, P. J. Park# and C. A. Walsh#

Science 359, 555-559 10.1126/science.aao4426. Covered in Yahoo! News, GenomeWeb, and others.



Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

M. J. McConnell, J. V. Moran, A. Abyzov, S. Akbarian, T. Bae, I. Cortes-Ciriano, J. A. Erwin, L. Fasching, D. A. Flasch, D. Freed, J. Ganz, A. E. Jaffe, K. Y. Kwan, M. Kwon, M. A. Lodato, R. E. Mills, A. C. M. Paquola, R. E. Rodin, C. Rosenbluh, N. Sestan, M. A. Sherman, J. H. Shin, S. Song, R. E. Straub, J. Thorpe, D. R. Weinberger, A. E. Urban, B. Zhou, F. H. Gage, T. Lehner, G. Senthil, C. A. Walsh, A. Chess, E. Courchesne, J. G. Gleeson, J. M. Kidd, P. J. Park, J. Pevsner, F. M. Vaccarino and N. Brain Somatic Mosaicism Network

Science 35610.1126/science.aal1641


PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation

M. A. Sherman, A. R. Barton, M. A. Lodato, C. Vitzthum, M. E. Coulter, C. A. Walsh and P. J. Park

Nucleic Acids Research10.1093/nar/gkx1195



Somatic mutation in single human neurons tracks developmental and transcriptional history

M. A. Lodato*, M. B. Woodworth*, S. Lee*, G. D. Evrony, B. K. Mehta, A. Karger, S. Lee, T. W. Chittenden, A. M. D'Gama, X. Cai, L. J. Luquette, E. Lee, P. J. Park# and C. A. Walsh#

Science 350, 94-8.

Covered in the Wall Street Journal, The Atlantic, Science, Scientific American, and others.


Full List of Publications

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