Selected Publications
Lodato lab members in bold

2022

 

Choudhury, S., Huang, A.Y., Kim, J., Zhou, Z., Morillo, K., Maury, E.A., Tsai, J.W., Miller, M.B., Lodato, M.A., Araten, S., Hilal, N., Lee, E.A.#, Chen, M.H.#, Walsh, C.A#. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nature Aging. doi.org/10.1038/s43587-022-00261-5. Link

Miller, M.B.*, Huang, A.Y.*, Kim, J., Zhou, Z., Kirkham, S.L., Maury, E.A., Ziegenfuss, J.S., Reed, H.C., Neil, J.E., Rento, L., Ryu, S.C., Ma, C.C., Luquette, L.J., Ames, H.M., Oakley, D.H., Frosch, M.P., Hyman, B.T., Lodato, M.A.#, Lee, E.A.#, and Walsh, C.A.# Somatic genomic changes in single Alzheimer's disease neurons. Nature.10.1038/s41586-022-04640-1.Link

Covered in The Boston Globe, AlzForum, U.S. News and World Report, and others.

Bourseguin, J., Cheng, W., Talbot, E., Hardy, L., Lai, J., Jeffries, A.M., Lodato, M.A., Lee, E.A., Khoronenkova, S.V. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic Acids Research. https://doi.org/10.1093/nar/gkac104. Link

2021

 

Lai, J., Kim, J., Jeffries, A.M., Tolles, A., Chittenden, T.W., Buckley, P.G., Yu, T.W., Lodato, M.A#., Lee, E.A.# Single-nucleus transcriptomic analyses reveal microglial activation underlying cerbellar degeneration in Ataxia Telangiectasia. bioRxiv, https://doi.org/10.1101/2021.09.09.459619 Link

 

Luquette, L.J., Miller, M.B., Zhou, Z., Bohrson, C.L., Galor, A., Lodato, M.A., Gawad, C., West, J., Walsh, C.A., Park,. P.J. Ultraspecific somatic SNV and indel detections in single neurons using primary template-directed amplification. bioRxiv. https://doi.org/10.1101/2021.04.30.442032. Link

2020

 

Kim, J., Zhao, B., Huang, A.Y., Miller, M.B., Lodato, M.A., Walsh, C.A., and Lee, E.A. APP gene copy number changes reflect exogenous contamination. Nature 584, E20-E28. Link

 

2019

 

Lodato, M.A., and Walsh, C.A. Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms. Hum Mol Genet 28, R197-R206. Link

 

Bohrson, C.L., Barton, A.R., Lodato, M.A., Rodin, R.E., Luquette, L.J., Viswanadham, V.V., Gulhan, D.C., Cortes-Ciriano, I., Sherman, M.A., Kwon, M., et al. Linked-read analysis identifies mutations in single-cell DNA-sequencing data. Nat Genet 51, 749-754. Link

 

2018

 

Lodato, M.A*., Rodin, R.E*., Bohrson, C.L*., Coulter, M.E*., Barton, A.R*., Kwon, M*., Sherman, M.A., Vitzthum, C.M., Luquette, L.J., Yandava, C., et al. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science 359, 555-559. Link

Covered in Yahoo! News, GenomeWeb, and others.

 

2017

 

Sherman, M.A., Barton, A.R., Lodato, M.A., Vitzthum, C., Coulter, M.E., Walsh, C.A., and Park, P.J. PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic Acids Res. Link

 

McConnell, M.J., Moran, J.V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J.A., Fasching, L., Flasch, D.A., Freed, D., Ganz, J., Jaffe, A.E., Kwan, K.Y., Kwon, M., Lodato, M.A., Mills, R.E., Paquola, A.C.M., Rodin, R.E., Rosenbluh, C., Sestan, N., Sherman, M.A., Shin, J.H., Song, S., Straub, R.E., Thorpe, J., Weinberger, D.R., Urban, A.E., Zhou, B., Gage, F.H., Lehner, T., Senthil, G., Walsh, C.A., Chess, A., Courchesne, E., Gleeson, J.G., Kidd, J.M., Park, P.J., Pevsner, J., Vaccarino, F.M., and Brain Somatic Mosaicism, N. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science.10.1126/science.aal1641. Link

 

2015

 

Lodato, M.A*., Woodworth, M.B.*, Lee, S.*, Evrony, G.D., Mehta, B.K., Karger, A., Lee, S., Chittenden, T.W., D'Gama, A.M., Cai, X., et al. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science 350, 94-98. Link

Covered in the Wall Street Journal, The Atlantic, Science, Scientific American, and others.

 

Full List of Publications

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